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Interactions of GSK-3β with mitochondrial permeability transition pore modulators during preconditioning:

Jiang Zhu1, Mario J Rebecchi, Peter S A Glass

  • 1Department of Anesthesiology, Stony Brook University School of Medicine, HSC L4 060, NY 11794, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|October 17, 2012
PubMed
Summary

Anesthetic preconditioning (APC) and ischemic preconditioning (IPC) lose effectiveness with aging. This study reveals age-related failures in molecular pathways that protect the heart during stress, impacting mitochondrial function.

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