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Updated: May 17, 2026
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Hybrid scaffolds built from PET and collagen as a model for vascular graft architecture
Mariana C Burrows1, Vitor M Zamarion, Fabíola B Filippin-Monteiro
1Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, Brazil.
Abstract:
A hybrid material with excellent mechanical and biological properties is produced by electrospinning a co-solution of PET and collagen. The fibers are mapped using SEM, confocal Raman microscopy and collagenase digestion assays. Fibers of different compositions and morphologies are intermingled within the same membrane, resulting in a heterogeneous scaffold. The collagen distribution and exposure are found to depend on the PET/collagen ratio. The materials are chemically and mechanically characterized and biologically tested with fibroblasts (3T3-L1) and a HUVEC culture in vitro. All of the hybrid scaffolds show better cell attachment and proliferation than PET. These materials are potential candidates to be used as vascular grafts.
