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Updated: May 17, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Guilt by association: what p120-catenin has to hide
Mirna Perez-Moreno1, Elaine Fuchs
1BBVA Foundation-Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid 28019, Spain. maperez@cnio.es
Abstract:
Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics.
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