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Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

Group Design

Group Design

The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between the two are due to...

Crossover Experiments

Crossover Experiments

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Experimental Designs

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An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...

Blinding

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Related Experiment Video

Updated: May 17, 2026

A Within-Subject Experimental Design using an Object Location Task in Rats

A Within-Subject Experimental Design using an Object Location Task in Rats

Published on: May 6, 2021

Single-subject experimental design for evidence-based practice.

Breanne J Byiers¹, Joe Reichle, Frank J Symons

¹University of Minnesota, Minneapolis, USA. byier001@umn.edu

American Journal of Speech-Language Pathology

|October 17, 2012

Summary

This summary is machine-generated.

Single-subject experimental designs (SSEDs) offer a flexible approach for evidence-based practice in communication sciences and disorders. This review covers SSED strategies, application in speech-language pathology, and data analysis for research.

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Area of Science:

Communication Sciences and Disorders
Speech-Language Pathology Research

Background:

Single-subject experimental designs (SSEDs) are crucial for evidence-based practice.
SSEDs offer an alternative to traditional group research designs.

Purpose of the Study:

To review the strategies and tactics of SSEDs.
To examine the application of SSEDs in speech-language pathology research.

Main Methods:

Discussion of SSED requirements, advantages, and disadvantages.
Review of effect evaluation logic and contemporary data analysis issues.
Inclusion of challenges and specific research exemplars.

Main Results:

SSEDs provide a flexible methodology for research.
The review details practical aspects and analytical considerations for SSEDs.

Conclusions:

SSED studies are a viable alternative to group designs.
SSEDs facilitate the development and identification of evidence-based practices in communication sciences and disorders.