Related Experiment Video
Updated: May 17, 2026
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies
Bingbing Wei1, Zhuoqun Xu, You Zhou
1Department of Urology, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
Background:
Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.
Methodology/Principal Findings:
A comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11-1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03-1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96-1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa.
Conclusions/Significance:
The present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.
