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Updated: May 17, 2026
11:53
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
Published on: July 3, 2018
TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network
Young-Cheul Shin1, Soo-Yong Shin, Jung Nyeo Chun
1Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Plos One
|October 17, 2012
Summary
The TRIP Database 2.0 enhances access to TRP channel protein-protein interaction data. This updated resource aids researchers in understanding TRP channel functions and disease roles.
Area of Science:
- Molecular Biology
- Biochemistry
- Bioinformatics
Background:
- Transient receptor potential (TRP) channels are critical Ca(2+)-permeable cation channels involved in numerous biological and disease processes.
- Existing resources for TRP channel protein-protein interactions (PPIs) require improved accessibility and data utilization for advanced research.
Purpose of the Study:
- To present the TRIP Database 2.0, an enhanced manually curated resource for TRP channel PPIs.
- To improve information accessibility and facilitate data-driven research in the TRP channel field.
Main Methods:
- Manual curation of PPI information from supplementary data of scientific articles.
- Development of user-friendly web interfaces, including a PPI summary matrix.
- Expansion of search capabilities to include PubMed and PIE search.
- Provision of PPI data in sif file format for network analysis with Cytoscape.
Main Results:
- TRIP Database 2.0 offers improved accessibility to manually curated TRP channel PPI data.
- New features facilitate intuitive understanding and retrieval of interaction information.
- Expanded search functions enhance data discovery from multiple sources.
- Data availability in sif format supports network visualization and analysis.
Conclusions:
- TRIP Database 2.0 serves as a comprehensive information hub for TRP channel research.
- The enhanced resource empowers researchers with tools for knowledge acquisition and novel approaches to studying TRP channel functions.
- This database advances data-driven research into the roles of TRP channels in biological and disease processes.
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