Developing micro-/nanoparticulate drug delivery systems using "design of experiments".
Bhupinder Singh1, Rahul Bhatowa, Chandra Bhushan Tripathi
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India .
International Journal of Pharmaceutical Investigation
|October 17, 2012
Summary
Micro and nanoparticles offer improved drug delivery. This review highlights the Design of Experiments (DoE) approach for optimizing micro/nanoparticulate systems, moving beyond traditional trial-and-error methods for better formulation development.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Micro and nanoparticulate systems are crucial for advanced drug delivery due to enhanced control and targeting.
- Their small size and surface properties enable specific applications like lymphatic and brain targeting.
- Traditional formulation development relies on inefficient "trial and error" (OVAT) methods, hindering true optimization.
Purpose of the Study:
- To provide an updated overview of the Design of Experiments (DoE) approach for microparticle and nanostructured system formulation.
- To review experimental designs and optimization techniques applicable to DoE in this field.
- To compile examples of micro/nanoparticulate systems successfully optimized using DoE.
Main Methods:
- Review of existing literature on Design of Experiments (DoE) applications in micro/nanoparticulate drug delivery system formulation.
- Analysis of various experimental designs and optimization strategies within DoE.
- Compilation and categorization of previously optimized micro/nanoparticulate systems using DoE.
Main Results:
- DoE offers a systematic and efficient alternative to OVAT for optimizing micro/nanoparticulate formulations.
- Various DoE methodologies and optimization techniques are applicable to the development of these systems.
- A comprehensive list of micro/nanoparticulate systems optimized via DoE is presented.
Conclusions:
- The Design of Experiments (DoE) approach is essential for systematic and efficient optimization of micro/nanoparticulate drug delivery systems.
- This review serves as a guide for researchers in developing and optimizing advanced drug delivery formulations.
- Encourages the adoption of DoE for future research in pharmaceutical micro/nanotechnology.
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