Related Experiment Video
Updated: May 17, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
Published on: December 13, 2024
Effect of agar-gelatin compositions on the release of salbutamol tablets
Anita Saxena1, Abu Tahir, Mandeep Kaloti
1School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory, Jawaharlal Nehru University, New Delhi, India .
Abstract:
The study was designed for the development of salbutamol-modified release tablet using various polymer composition of agar, gelatin A and gelatin B. The purpose is to observe the role of polymer composition on the modified dissolution rate of salbutamol. Pre-formulation trials were initiated by comprising different ratios of polymer blend in the tablets. Formulations were optimized based on their invitro release performed in enzyme free simulated gastric fluid (0.1 N HCl, pH 1.2). Dissolution profiles of tablets were compared among the tablets made of agar, gelatin A, gelatin B and their blends agar-gelatin A, agar-gelatin B, gelatin A-gelatin B and agar-gelatin A-gelatin B in 1:1 ratio. Polymer compositions were fixed based on our desired sustaining activity of the tablet which showed a biphasic release profile with immediate release followed by sustained release. Polymer blends were more effective in controlling drug release. The better controlling behavior of polymer blends was explained by specific interaction between polymer components, their network structure and polymer-drug interaction.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
In Vitro Drug Dissolution: Compendial Testing Models I
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
