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A novel herbal formulation in the management of diabetes
Santosh S Bhujbal1, Sunita S Hadawale, Parag A Kulkarni
1Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
Background And Aim:
Momordica charantia Linn. is traditionally used as a medicine for diabetes. The present investigation was aimed to formulate and evaluate transdermal patchesof Momordica charantia Linn.
Materials And Methods:
The transdermal films containing the herbal drug component fractionated fromethanolicextract of M. charantia fruits were prepared by using hydroxy propyl methyl cellulose as a polymer. The films were evaluated for folding endurance, thickness, weight variation, drug contents and in vitro diffusion studies and in vivo parameterslike acute and sub-acute antihyperglycemic activity in diabetic rats, biochemicalstudies, skin irritation in rats and stability studies.
Result And Discussion:
The weightof transdermal patches of M. charantia (2 cm(2); 10 mg/patch) and was found to be 0.03 gm.Thickness of patches of M. charantia (2 cm(2); 10 mg/patch) was found to be satisfactory. The percentage release of active constituents from transdermal patches of M.charantia (2 cm(2); 10 mg/patch) was found to be 47.59% in 10% hydroalcoholic phosphate buffer pH 7.4 at the end of 6 h.The transdermal route exhibited negligible skin irritation and in vivo results revealed that the patches successfully decrease the blood glucose level.
Conclusion:
From the results, we concluded that the well-known herbal drug M. charantia Linn. have been found to be effective for diabetes through modern pharmaceutical formulation techniques.
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