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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Drug delivery systems: An updated review
Gaurav Tiwari1, Ruchi Tiwari, Birendra Sriwastawa
1Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.
International Journal of Pharmaceutical Investigation
|October 17, 2012
Summary
Nasal and pulmonary drug delivery offer alternatives to injections, especially for protein therapeutics. Biodegradable polymer nanoparticles show promise for effective and safe delivery via these routes.
Area of Science:
- Pharmacology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Nasal and pulmonary drug delivery are increasingly important for treating human diseases.
- These routes offer alternatives to parenteral administration, particularly for peptide and protein therapeutics.
- Various drug delivery systems are being explored for nasal and pulmonary applications.
Purpose of the Study:
- To review and highlight the potential of various drug delivery systems for nasal and pulmonary administration.
- To emphasize the suitability of biodegradable polymer nanoparticles for these advanced drug delivery routes.
Main Methods:
- Review of existing literature on nasal and pulmonary drug delivery systems.
- Analysis of formulation strategies including liposomes, microspheres, and nanoparticles.
- Evaluation of nanoparticle properties relevant to aerosolization and in vivo performance.
Main Results:
- Nasal and pulmonary routes bypass first-pass metabolism, enhancing bioavailability.
- Biodegradable polymer nanoparticles demonstrate key characteristics for aerosolization and targeted delivery.
- Nanoparticles offer controlled drug release and predictable degradation profiles.
Conclusions:
- Biodegradable polymer nanoparticles are a promising platform for nasal and pulmonary drug delivery.
- These systems meet critical requirements for efficient and safe administration of therapeutics.
- Further research into nanoparticle-based drug delivery can advance treatment options.
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