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Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid
J Helgestad1, R Pettersen, I Storm-Mathisen
1Department of Pediatric Research, National Hospital of Norway, Oslo.
European Journal of Haematology
|January 1, 1990
Summary
A novel human malignant T-cell line, PFI-285, was established from lymphoma. These cells exhibit unique ascorbic acid sensitivity, offering potential therapeutic avenues.
Area of Science:
- Immunology
- Cell Biology
- Oncology
Background:
- Malignant lymphoma involves uncontrolled lymphocyte proliferation.
- Establishing and characterizing new cell lines is crucial for cancer research.
- Understanding T-cell behavior and growth factor independence is key.