Related Experiment Video
Updated: May 17, 2026

Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas
Published on: July 25, 2025
Study on blood glucose concentration in patients with diabetes undergoing dental extraction under local anesthesia
Irfan Ul Hassan Haji1, Mohamed Siddiq, Sripathi Rao
1Department of Oral and Maxillofacial Surgery, Bhopal, India. dr.irfanhaji@yahoo.com
Background:
The aim of this study was to compare the effect of adrenaline on blood glucose concentration in patients with diabetes undergoing tooth extraction under local anesthesia and also to find out whether blood glucose concentration differs if local anesthetics are injected in clinical doses with and without adrenaline.
Methods:
Patients included had a tooth in need of extraction, were in the 25-55 years age group, had a random blood sugar level ≤140 mg/dL and were on oral antidiabetic drugs. The 25 patients in Group A were injected with 2 mL of lignocaine hydrochloride without adrenaline (xylocaine 2%) and the other 25 patients (Group B) were injected with 2 mL lignocaine hydrochloride along with adrenaline 1:80,000. Serial blood glucose estimations were made at regular intervals of 10 min before local anesthesia and subsequently 10 and 20 min after local anesthesia.
Results:
A statistically significant difference of the mean blood glucose concentration was noticed at three different time intervals between the two groups.
Conclusions:
Dental local anesthetic solutions containing adrenaline may safely be used in patients with diabetes who had taken their hypoglycemic medications preoperatively.
Related Concept Videos
Hypoglycemia and Glucagon
Hypoglycemia
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
SBAR II: Application of SBAR
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Hyperglycemia
Diabetes: Symptoms, Diagnosis, and Complications

