Related Experiment Video
Updated: May 17, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Mass spectrometry: a revolution in clinical microbiology?
Jean-Philippe Lavigne1, Paula Espinal, Catherine Dunyach-Remy
1Institut National de la Santé et de la Recherche Médicale, U1047 UFR de Médecine, CS83021, 186 Chemin du Carreau de Lanes, 30908, Nîmes Cedex 02, France. jean.philippe.lavigne@chu-nimes.fr
Abstract:
Recently, different bacteriological laboratory interventions that decrease reporting time have been developed. These promising new broad-based techniques have merit, based on their ability to identify rapidly many bacteria, organisms difficult to grow or newly emerging strains, as well as their capacity to track disease transmission. The benefit of rapid reporting of identification and/or resistance of bacteria can greatly impact patient outcomes, with an improvement in the use of antibiotics, in the reduction of the emergence of multidrug resistant bacteria and in mortality rates. Different techniques revolve around mass spectrometry (MS) technology: matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), PCR combined with electrospray ionization-mass spectrometry (PCR/ESIMS), iPLEX MassArray system and other new evolutions combining different techniques. This report emphasizes the (r)evolution of these technologies in clinical microbiology.
More Related Videos
09:49Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Published on: November 18, 2022
09:43Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics (MSPP)
Published on: October 30, 2016
Related Concept Videos
MALDI-TOF Mass Spectrometry
Tandem Mass Spectrometry
Automated Microbial Diagnostics
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Modern Molecular Taxonomy
Mass Spectrometry: Overview