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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα
Rani A Jose1, Arnout Voet, Katleen Broos
1Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Box 2404, 3001 Heverlee, Belgium.
Chemical Communications (Cambridge, England)
|October 18, 2012
Abstract:
An integrated approach comprising STD NMR screening, pharmacophore based analogue selection and a bioassay is presented for the discovery of a stabilizer of the clinically relevant VWF-GPIbα protein-protein interaction.
