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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Hyperglycemia within day 14 of aneurysmal subarachnoid hemorrhage predicts 1-year mortality

Liheng Bian1, Liping Liu, Chunxue Wang

  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Clinical Neurology and Neurosurgery
|October 18, 2012
PubMed

Insights

High admission and fluctuating glucose levels in patients with subarachnoid hemorrhage (SAH) predict increased 1-year mortality. Monitoring blood glucose is crucial for predicting outcomes in SAH patients without diabetes.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Critical Care Medicine

Background:

  • Subarachnoid hemorrhage (SAH) is a critical neurological condition.
  • Glycemic control is increasingly recognized as a significant factor in patient outcomes across various medical conditions.

Purpose of the Study:

  • To investigate the association between fasting glucose levels on admission, day 14, and their variation with 1-year mortality in patients with SAH.
  • To identify glucose level dynamics as potential predictors of mortality following SAH.

Main Methods:

  • A prospective study involving 239 SAH patients without a history of diabetes.
  • Analysis of fasting glucose levels at admission and day 14, along with their changes.
  • Multivariate Cox regression analysis to determine risk factors for 1-year mortality.

Main Results:

  • 1-year mortality rate was 11.7% in the studied cohort.
  • Admission glucose levels were significantly associated with 1-year mortality (HR: 1.524 per mmol/L).
  • Increased fasting glucose levels within 14 days and higher glucose levels in non-survivors were observed, correlating with elevated 1-year mortality (HR: 1.350 per mmol/L).

Conclusions:

  • Fasting glucose levels upon admission and their subsequent variation in SAH patients are significant predictors of 1-year mortality.
  • These findings highlight the importance of glycemic monitoring in managing SAH patients.
Abstract

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