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Hodgkin lymphoma in children: experience in a tertiary care centre in India

Amita Trehan1, Shaveta Singla, Ram K Marwaha

  • 1Division of Pediatric Hematology Oncology, Advanced Pediatric Centre, Chandigarh, India. trehanamita@hotmail.com

Journal of Pediatric Hematology/Oncology
|October 18, 2012
PubMed

Insights

Pediatric Hodgkin lymphoma (HL) in developing countries shows distinct epidemiological features but achieves comparable treatment outcomes. Chemotherapy alone demonstrates excellent results in children with HL, regardless of the epidemiological profile.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Epidemiology

Background:

  • Hodgkin lymphoma (HL) in developing nations presents with a higher male-to-female ratio, younger age at diagnosis, advanced stage disease, constitutional symptoms, and a predominance of mixed cellularity histology.
  • Treatment outcomes in these regions appear comparable to those in developed countries.

Purpose of the Study:

  • To analyze the clinical characteristics and treatment outcomes of pediatric Hodgkin lymphoma patients in a developing country.
  • To evaluate the effectiveness of chemotherapy in this patient population.

Main Methods:

  • Retrospective analysis of 206 children diagnosed and treated for Hodgkin lymphoma between 1990 and 2006.
  • Data collected included age, stage at diagnosis, presence of B symptoms, histologic type, treatment received, and survival rates.

Main Results:

  • The majority of patients (52%) presented with advanced-stage disease (III-IV), 54% had B symptoms, and 69.6% had mixed cellularity HL.
  • The 5-year overall survival and event-free survival rates were 92.7% and 77.75%, respectively.
  • Children with early-stage disease and no B symptoms had significantly better survival rates.

Conclusions:

  • Despite a different epidemiological profile, pediatric Hodgkin lymphoma in developing countries can achieve favorable outcomes.
  • Chemotherapy alone is an effective treatment modality for children with Hodgkin lymphoma, yielding excellent results.
Abstract

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