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Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

David Karasek1, Helena Vaverkova, Milan Halenka

  • 1Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Czech Republic. david.karasek@fnol.cz

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|October 18, 2012
PubMed

Insights

Prehypertension and hypertension are more common in individuals with dyslipidemia, particularly hypertriglyceridemia. These conditions are linked to increased intima-media thickness, indicating higher cardiovascular risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Prehypertension, like hypertension, is a risk factor for cardiovascular disease.
  • Dyslipidemia is a common metabolic disorder associated with increased cardiovascular risk.

Purpose of the Study:

  • To determine the prevalence of prehypertension and hypertension across different dyslipidemic phenotypes.
  • To examine the relationship between blood pressure and other atherosclerotic risk factors.
  • To assess the atherogenic impact of prehypertension using carotid intima-media thickness (IMT).

Main Methods:

  • 667 asymptomatic subjects were categorized into four dyslipidemic phenotypes based on apolipoprotein B (apoB) and triglycerides (TG) levels.
  • Dyslipidemic Phenotype 1 (DLP1) with normal apoB/TG served as the control group.
  • Measurements included blood pressure, lipid profiles, and carotid IMT.

Main Results:

  • Prehypertension and hypertension were significantly more prevalent in all dyslipidemic groups compared to the normolipidemic control group.
  • Blood pressure correlated with age, lipids, BMI, and waist circumference, with specific correlations for SBP and DBP with other metabolic markers.
  • Intima-media thickness (IMT) was elevated in prehypertensive and hypertensive subjects across all dyslipidemic phenotypes.

Conclusions:

  • Dyslipidemia is associated with a higher prevalence of prehypertension and hypertension.
  • Hypertriglyceridemic individuals exhibited the highest combined prevalence of prehypertension and hypertension.
  • Elevated IMT in prehypertensive and hypertensive individuals underscores their increased cardiovascular risk.
Abstract

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