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Updated: May 17, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Analysis of risk factors in development of thrombosis in patients with antiphospholipid syndrome]
Ru Li1, Yun-shan Zhou, Yuan Jia
1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Objective:
To analyze the risk factors in the development of thrombosis in antiphospholipid syndrome (APS) patients.
Methods:
We retrospectively analyzed the characteristics of thrombosis in 61 APS patients. Clinical and laboratory parameters such as sex, age, thrombocytopenia, smoking, hypertension, diabetes mellitus, hyperlipidemia and anti-phospholipid antibodies were investigated to find out the risk factors of thrombosis.
Results:
Thrombosis was found in 70.49% APS patients, of whom, the prevalence of arterial and venous thrombosis were 36.67% and 39.34%, respectively. Deep vein thrombosis of lower extremity (37.7%) and cerebral infarction (24.59%) were the most common thrombosis events, and then pulmonary embolism, thrombotic microangiopathy and renal artery thrombosis were also common in APS patients. The positive anti-cardiolipin antibody and hypertension were the independent risk factors for venous and arterial thrombosis, respectively.
Conclusion:
Anti-cardiolipin antibody is associated with a higher risk of venous thrombosis, and hypertension is associated with arterial thrombosis.
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