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Related Experiment Video

Updated: May 17, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

[Renal denervation: current state and future perspectives].

K Kara1, H Bruck, P Kahlert

  • 1Klinik für Kardiologie, Westdeutsches Herzzentrum, Universitätsklinikum Essen, Universität Essen-Duisburg, Hufelandstr. 55, 45147, Essen, Deutschland. kaffer.kara@uk-essen.de

Herz
|October 18, 2012
PubMed
Summary
This summary is machine-generated.

Resistant hypertension, often unresponsive to medication, may be treated with renal denervation. This procedure reduces sympathetic nerve activity in the kidneys, potentially lowering blood pressure and improving related conditions.

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 17, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Context:

  • Resistant hypertension affects 5-15% of hypertensive patients in Germany, despite multiple antihypertensive drugs.
  • Elevated sympathetic nervous system activity plays a key role in resistant hypertension.
  • Traditional surgical sympathectomy, though effective, was highly invasive.

Purpose:

  • To explore catheter-based renal sympathetic denervation as a novel treatment for uncontrolled hypertension.
  • To evaluate the impact of renal denervation on blood pressure and associated conditions.

Summary:

  • Renal sympathetic denervation uses radiofrequency ablation to eliminate nerve fibers in renal arteries, reducing sympathetic activity.
  • Early trials like Symplicity HTN-1 and HTN-2 demonstrated significant reductions in systolic and diastolic blood pressure.
  • Potential benefits extend to glucose metabolism, sleep apnea, and heart/renal failure, though further research is needed.

Impact:

  • Renal denervation shows promise for selected patients with resistant hypertension.
  • Further large-scale trials and longer follow-up are required to confirm efficacy and the value of newer devices.
  • Currently, it is not a standard therapy for hypertension or a replacement for medical treatment.