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Updated: May 17, 2026

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance
Erika Cristina Jorge1, Mohi U Ahmed, Ingo Bothe
1Universidade Federal de Minas Gerais-Departamento de Morfologia, Belo Horizonte, MG, Brazil. ecjorge@icb.ufmg.br
Background:
Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non-neural tissues.
Results:
To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb, the only RGM molecules currently known for avians, in the chicken embryo.
Conclusions:
Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development.
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