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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Phenazepam and its effects on driving.
Jon B Stephenson1, David E Golz, Mary Jo Brasher
1GBI Division of Forensic Sciences, Decatur, Georgia, USA. Jon.Stephenson@gbi.ga.gov
Journal of Analytical Toxicology
|October 18, 2012
Summary
Phenazepam, a recreational drug, impairs driving ability by causing central nervous system depression. Even low doses can significantly impact psychomotor skills, posing risks on the road.
Area of Science:
- Forensic Toxicology
- Pharmacology
- Drug Enforcement
Background:
- Phenazepam use is rising as a recreational drug in Georgia.
- Understanding its effects on driving is crucial for public safety.
Purpose of the Study:
- To examine the psychomotor effects of phenazepam.
- To assess its impact on the ability to operate a motor vehicle.
Main Methods:
- Reviewed 11 impaired driving cases in Georgia (March 2010-August 2011).
- Analyzed blood samples for phenazepam and other drugs.
- Correlated drug concentrations with observed impairment symptoms.
Main Results:
- Five cases involved only phenazepam; six involved multiple drugs.
- Phenazepam concentrations ranged from 0.04 to 3.2 mg/L (median 0.17 mg/L).
- Observed effects included slurred speech, poor balance, slow reactions, drowsiness, and confusion.
Conclusions:
- Phenazepam use, even at low concentrations similar to other benzodiazepines, significantly impairs driving ability.
- Central nervous system depression is a key effect impacting psychomotor skills.
- This highlights the risks associated with phenazepam in recreational drug markets.
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