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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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The Hedgehog signal transduction network.

David J Robbins1, Dennis Liang Fei, Natalia A Riobo

  • 1Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. drobbins@med.miami.edu

Science Signaling
|October 18, 2012
PubMed
Summary
This summary is machine-generated.

Hedgehog (Hh) signaling, crucial for development and implicated in diseases, involves canonical pathways regulating Gli transcription factors. Emerging research reveals noncanonical pathways, offering new insights into Hh

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signaling

Background:

  • Hedgehog (Hh) proteins are vital regulators of metazoan embryonic and adult development.
  • Disruptions in Hh signaling pathways are linked to various human diseases.
  • Understanding Hh signaling is critical for both developmental biology and disease research.

Purpose of the Study:

  • To provide a comprehensive review of Hh signaling pathways.
  • To consolidate data from diverse organisms and scientific disciplines.
  • To highlight the evolution of understanding Hh signaling from canonical to noncanonical mechanisms.

Main Methods:

  • Literature review and data consolidation.
  • Analysis of existing studies on Hh signaling mechanisms.
  • Synthesis of information on canonical and noncanonical Hh pathways.

Main Results:

  • Hh signaling knowledge initially focused on the canonical pathway involving Gli transcription factors.
  • Recent studies identify Gli-independent, noncanonical Hh signaling pathways.
  • Noncanonical pathways are further divided into Smoothened (Smo)-dependent and Smo-independent modules.

Conclusions:

  • Hh signaling is more complex than previously thought, involving multiple context-dependent modules.
  • Noncanonical pathways represent a significant expansion of Hh signaling mechanisms.
  • These diverse pathways can interact and crosstalk, forming a dynamic signaling network.