[Cellular changes in the paraurethral zone of the experimental animals in exposure to collost gel]

An experimental trial of the collagen gel collost was made on Wistar white female rats aged 68 and 30-36 months. 7 and 15% collost gel (the first Russian collagen gel produced from cattle skin) was implanted in paraurethral region of the animals. The connective tissue cells in the zone of collost gel injection was studied histologically, immunohistochemically, electron microscopically. The examinations revealed differences in the content of the connective tissue in the injection zone depending on a collagen concentration and the age of the animal. The findings suggest that 15% collost gel implantation in the form of a paraurethral injection may be effective in females suffering from stress urinary incontinence for narrowing urethral lumen and preventing spontaneous voiding in response to a rise of intraabdominal pressure.