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Updated: May 17, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Nutritional targets to enhance exercise performance in chronic obstructive pulmonary disease
Coby van de Bool1, Michael C Steiner, Annemie M W J Schols
1Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Nutrition may enhance exercise in chronic obstructive pulmonary disease (COPD), but more research is needed. While some supplements show promise, evidence for their ergogenic aid effect in COPD patients is limited.
Area of Science:
- Exercise physiology
- Nutritional science
- Pulmonary rehabilitation
Background:
- Chronic obstructive pulmonary disease (COPD) is associated with altered body composition and skeletal muscle dysfunction.
- Muscle impairments in COPD include reduced oxidative metabolism and increased oxidative stress.
- Muscle wasting in COPD may be linked to vitamin D and branched-chain amino acid deficiencies.
Purpose of the Study:
- To review the rationale and efficacy of nutrition as an ergogenic aid for exercise and training in COPD.
- To explore the potential of nutritional interventions to improve exercise capacity in COPD patients.
Main Methods:
- Review of current knowledge on nutrition and exercise in COPD.
- Analysis of clinical trial evidence for nutritional supplementation.
- Examination of metabolic routes and targets for intervention.
Main Results:
- Exercise training benefits COPD patients, but direct evidence for nutritional interventions enhancing performance is lacking.
- Polyunsaturated fatty acids may improve exercise capacity in COPD when combined with training.
- Conflicting results exist for creatine, glutamate, and glutamine supplementation; visceral fat is a potential target.
Conclusions:
- There is a need for well-powered, controlled trials to determine the role of nutritional supplementation in COPD.
- Further research is required to establish the effectiveness of ergogenic aids in enhancing exercise performance and managing systemic features of COPD.
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