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Updated: May 17, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Regioselective multicomponent sequential synthesis of hydantoins
Francesca Olimpieri1, Maria Cristina Bellucci, Tommaso Marcelli
1Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy.
Abstract:
The development of new practical and green methods for the synthesis of small heterocycles is an attractive area of research due to the well-known potential of heterocyclic small molecule scaffolds in the drug discovery process. Herein we report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins, in high yields and very mild conditions, using readily accessible starting materials such as azides, iso(thio)cyanates and substituted α-halo-acetic carboxylic acids. This methodology is especially convenient for the synthesis of spiro-hydantoins, which are particularly interesting bioactive compounds in medicinal chemistry.
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