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[Coronary plaques identified by coronary computed tomography angiography and the risk factors for major adverse
Bin He1, Luyue Gai, Jingjing Gai
1Department of Cardiology, General Hospital of PLA, Beijing, China. hebin_1998@163.com
Insights
Coronary computed tomography angiography (CCTA) findings correlate with major adverse cardiac events risk factors. The Framingham risk score, creatinine, homocysteine, and HDL effectively predict coronary plaques, aiding in coronary artery disease screening.
Area of Science:
- Cardiology
- Radiology
- Preventive Medicine
Background:
- Coronary artery disease (CAD) poses a significant health burden.
- Early identification of CAD risk factors is crucial for effective management.
- Coronary computed tomography angiography (CCTA) offers detailed visualization of coronary anatomy.
Purpose of the Study:
- To determine the association between CCTA findings and established cardiovascular risk factors.
- To evaluate the predictive value of various risk factors and scores for coronary plaque presence and severity.
Main Methods:
- A cohort study of 706 outpatients undergoing CCTA.
- Coronary artery disease severity was graded.
- Pearson correlation, ANOVA, and ROC curve analysis were employed.
Main Results:
- Over 58% of patients had abnormal CCTA findings.
- Older age, hypertension, hyperlipidemia, diabetes, and prior cardiac events were linked to increased coronary plaques.
- Framingham score, LDL, HCY, IMT, HDL, and TC correlated with plaque severity. Framingham score, Cr, HCY, IMT, and HDL demonstrated significant predictive value.
Conclusions:
- CCTA findings are strongly associated with traditional cardiovascular risk factors.
- The Framingham risk score, creatinine, homocysteine, IMT, and HDL are validated by CCTA as key predictors of coronary plaques.
- These validated factors can be utilized for efficient screening of coronary artery disease.
Objective:
To investigate the correlation between the findings by coronary computed tomography angiography (CCTA) and the risk factors for major adverse cardiac events (MACE).
Methods:
This cohort study involved 706 out-patients who received examination with CCTA between June, 2008 and April, 2011. The severity of coronary artery disease (CAD) was graded to normal, mild, moderate, severe, and revascularization. Pearson correlation analysis and ANOVA were used to evaluate the relationship between the risk factors for CAD and coronary plaques identified by CCTA, and the predictive accuracy was determined by the receiver-operating characteristic (ROC) curve.
Results:
Of the 706 patients, 58.63% were found to have abnormal CCTA findings. A older age, hypertension, hyperlipidemia, diabetes mellitus, cerebral infarction, CAD, and myocardial infarction were associated with an significantly increased incidence of coronary plaques (P<0.01). The Framingham score, LDL, HCY, IMT, HDL and TC were also significantly correlated with the severity of the coronary plaques (P<0.05). The ROC curves showed that Framingham risk score (0.845), Cr (0.766), HCY (0.697), IMT (0.693) and HDL (0.316) had greater predictive value for the occurrence of coronary plaques (P<0.001).
Conclusion:
The Framingham risk score, Cr, HCY, IMT and HDL are validated by CCTA as the major coronary risk factors and can be used for screening of CAD.
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