[Individualized fluid-solid coupled model of intracranial aneurysms based on computed tomography angiography data]

Area of Science:

• Biomedical Engineering
• Computational Fluid Dynamics
• Medical Imaging

Background:

• Intracranial aneurysms pose significant health risks.
• Accurate modeling is crucial for understanding aneurysm behavior.
• Existing models may not fully capture complex biomechanical interactions.

Purpose of the Study:

• To develop an individualized fluid-solid coupled model for intracranial aneurysms.
• To utilize computed tomography angiography (CTA) data for model creation.
• To analyze the biomechanical properties of aneurysms.

Main Methods:

• 3D reconstruction of patient-specific aneurysm geometry from CTA data using Mimics software.
• Simulation of blood flow and vascular wall interaction using ANSYS and CFX.
• Comparative analysis between fluid-solid coupled and rigid models.

Main Results:

• Successful establishment of a patient-specific fluid-solid coupled model.
• Simulation capabilities include blood flow, wall deformation, pressure, and stress fields.
• Model sensitivity analysis revealed that lower Young's modulus and greater wall thickness influence deformation; differences noted in wall shear stress and velocity compared to rigid models.

Conclusions:

• The fluid-solid coupled model provides a more accurate representation of intracranial aneurysms than rigid models.
• This computational approach offers reliable data for studying aneurysm initiation, growth, and rupture.
• Enables detailed analysis of hemodynamic forces and structural responses within aneurysms.