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Updated: May 17, 2026
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Differences between daytime and nighttime blood pressure variability regarding systemic atherosclerotic change and
Tatsuo Kawai1, Mitsuru Ohishi, Kei Kamide
1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
Summary
Blood pressure variability and arterial stiffness impact kidney function and atherosclerosis. Assessing both daytime and nighttime variations is key for managing hypertension and preventing cardiovascular disease.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Hypertension Research
Background:
- New hypertension parameters like blood pressure variability and ambulatory arterial stiffness index (AASI) correlate with arteriosclerotic changes.
- Understanding the relationship between circadian blood pressure patterns and vascular health is crucial.
Purpose of the Study:
- To investigate the correlation between circadian blood pressure/AASI variability and renal function.
- To examine the distinct clinical impacts of 24-hour, daytime, and nighttime blood pressure variability on renal and systemic atherosclerosis.
Main Methods:
- Analysis of data from 120 patients undergoing renal Doppler ultrasonography (RDU) and ambulatory blood pressure monitoring (ABPM).
- Correlation analysis between circadian blood pressure/AASI variability and renal function indicators like resistive index (RI) from RDU.
Main Results:
- Higher circadian systolic blood pressure (SBP) variability correlated with significantly higher RI, indicating increased renal vascular resistance.
- Daytime SBP variability showed a stronger correlation with RI than nighttime variability.
- Nighttime SBP variability, but not daytime, was linked to carotid atherosclerosis.
- AASI significantly correlated with RI.
- Daytime SBP standard deviation (s.d.) strongly correlated with renal vascular resistance; nighttime SBP s.d. correlated with intima-media thickness and plaque score.
Conclusions:
- Circadian variability in SBP and AASI are significantly correlated with renal function.
- Evaluating both daytime and nighttime blood pressure variability provides a comprehensive assessment of pathological conditions in hypertensive patients.
- This assessment aids in the prevention of cardiovascular diseases.
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