Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.

JACC. Basic to translational science·2026
Same author

Beta-Adrenergic Stimulation and <i>MYH7</i> G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance.

bioRxiv : the preprint server for biology·2026
Same author

Respiratory signal extraction from the electrocardiogram for risk stratification in cardiac patients.

European heart journal. Digital health·2026
Same author

Non-destructive transcriptomics via vesicular export.

Nature communications·2026
Same author

IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner.

Circulation research·2025
Same author

Correction: Implementation of the enhanced recovery after bariatric surgery (ERABS) protocol with clinical hypnosis: effects on pain and postoperative nausea and vomiting (PONV) management in bariatric surgery.

Surgical endoscopy·2025

Related Experiment Video

Updated: May 17, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Modeling long-QT syndromes with iPS cells.

Daniel Sinnecker1, Alexander Goedel, Tatjana Dorn

  • 1I. Medizinische Klinik Kardiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. sinnecker@tum.de

Journal of Cardiovascular Translational Research
|October 19, 2012
PubMed
Summary

Induced pluripotent stem cells (iPSCs) offer a source for patient-specific cells to study long-QT syndrome. These cells model disease aspects and may aid future drug screening and understanding of cardiac conditions.

More Related Videos

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Related Experiment Videos

Last Updated: May 17, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Area of Science:

  • Cardiovascular Research
  • Stem Cell Biology
  • Genetics

Background:

  • Induced pluripotent stem cells (iPSCs) can be generated from patient somatic cells.
  • Patient-specific iPSC lines provide a renewable source of cells with the patient's unique genotype.
  • Long-QT syndrome (LQTS) is a cardiac channelopathy affecting heart rhythm.

Purpose of the Study:

  • To investigate the utility of patient-specific iPSC-derived cardiomyocytes for studying LQTS.
  • To model key pathophysiological aspects of LQTS in vitro.
  • To explore potential applications in drug screening and disease mechanism research.

Main Methods:

  • Generation of iPSCs from human somatic cells of LQTS patients.
  • Differentiation of iPSCs into cardiomyocytes.
  • Analysis of cardiomyocyte electrophysiological properties and drug responses.

Main Results:

  • iPSC-derived cardiomyocytes recapitulated major LQTS phenotypes, including prolonged action potentials and arrhythmogenic activity.
  • The effects of pro- and antiarrhythmic drugs on LQTS cardiomyocytes were successfully modeled.
  • Patient-specific iPSC lines proved effective for in vitro disease modeling.

Conclusions:

  • Patient-specific iPSC-derived cardiomyocytes are a valuable tool for studying LQTS pathophysiology.
  • This technology holds promise for personalized medicine, including drug screening and understanding disease mechanisms.
  • Future applications may involve predicting drug efficacy and toxicity for individual patients.