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Published on: February 10, 2020
Red cell distribution width and mean platelet volume in amyloidosis
Emre Erdem1, Dilek Erdem, Melda Dilek
11Department of Nephrology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Summary
Red cell distribution width (RDW) and erythrocyte sedimentation rate (ESR) were higher in patients with reactive amyloid A (AA) amyloidosis, while mean platelet volume (MPV) was lower. These findings suggest RDW and MPV may aid in diagnosing inflammatory diseases like AA amyloidosis.
Area of Science:
- Hematology
- Immunology
- Internal Medicine
Background:
- Reactive amyloid A (AA) amyloidosis is a complication of chronic inflammatory diseases.
- Biomarkers for early detection and monitoring of AA amyloidosis are crucial.
- Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available hematological parameters.
Purpose of the Study:
- To investigate differences in RDW and MPV between patients with AA amyloidosis and healthy controls.
- To assess the potential of RDW and MPV as indicators in AA amyloidosis associated with chronic inflammation.
Main Methods:
- Retrospective analysis of 33 patients diagnosed with AA amyloidosis.
- Comparison with 40 age- and sex-matched healthy controls.
- Analysis of erythrocyte sedimentation rate (ESR), RDW, platelet count (PLT), and MPV levels from patient databases.
Main Results:
- Patients with AA amyloidosis exhibited significantly higher RDW, ESR, and PLT levels compared to controls (P < .0001).
- Mean platelet volume (MPV) was significantly lower in the AA amyloidosis group (P < .0001).
- Elevated RDW and decreased MPV were observed in individuals with AA amyloidosis.
Conclusions:
- Chronic inflammatory diseases, specifically AA amyloidosis, may be characterized by elevated RDW and low MPV.
- RDW and MPV show potential as accessible biomarkers for identifying patients with AA amyloidosis.
- Further research is warranted to validate these findings and explore their clinical utility in managing inflammatory conditions.
