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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a
Selma F Mohammed1, Barry A Borlaug, Véronique L Roger
1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Circulation. Heart Failure
|October 19, 2012
Summary
Heart failure with preserved ejection fraction (HFpEF) involves distinct cardiovascular changes beyond comorbidities. These underlying structural and functional alterations are key to understanding HFpEF, guiding targeted therapy development.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Endocrinology
Background:
- Heart failure with preserved ejection fraction (HFpEF) is linked to obesity and comorbidities, raising questions about its distinctness.
- The influence of comorbidities on cardiovascular structure and function in HFpEF requires clarification.
Purpose of the Study:
- To determine if HFpEF exhibits fundamental cardiovascular structural and functional alterations independent of body size and comorbidities.
- To investigate the specific impact of common comorbidities on HFpEF characteristics.
Main Methods:
- Comparison of comorbidity-adjusted cardiovascular parameters in HFpEF patients versus healthy and hypertensive controls.
- Analysis of clinical, structural, functional, and prognostic profiles within HFpEF patients based on individual comorbidities.
Main Results:
- HFpEF patients showed greater concentric hypertrophy, atrial enlargement, and systolic, diastolic, and vascular dysfunction compared to controls, even after adjusting for confounders.
- Comorbidities like obesity, anemia, diabetes, and renal dysfunction were associated with unique profiles within the HFpEF cohort.
Conclusions:
- HFpEF is characterized by fundamental cardiovascular changes distinct from its associated comorbidities.
- These findings support the development of mechanistically targeted therapies for HFpEF.
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