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Related Experiment Video

Updated: May 17, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Cranberries for preventing urinary tract infections.

Ruth G Jepson¹, Gabrielle Williams, Jonathan C Craig

¹Department of Nursing and Midwifery, University of Stirling, Stirling, UK. ruth.jepson@stir.ac.uk.

The Cochrane Database of Systematic Reviews

|October 19, 2012

Summary

Cranberry products do not significantly prevent urinary tract infections (UTIs). New research indicates cranberry juice is less effective than previously thought, with poor product standardization hindering reliable results.

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Area of Science:

Urology
Infectious Diseases
Evidence-Based Medicine

Background:

Cranberries have a long history of use for preventing and treating urinary tract infections (UTIs).
This review is an update of previous analyses conducted in 1998, 2004, and 2008.
The focus is on assessing the efficacy of cranberry products in susceptible populations.

Purpose of the Study:

To evaluate the effectiveness of cranberry products in preventing UTIs.
To analyze data from randomized controlled trials (RCTs) and quasi-RCTs.
To identify specific populations where cranberry products might be beneficial.

Main Methods:

Systematic search of major databases (MEDLINE, EMBASE, CENTRAL) and internet sources.
Inclusion of all RCTs and quasi-RCTs assessing cranberry products for UTI prevention.
Data extraction on study design, participants, interventions, and outcomes, with risk ratio calculations and narrative synthesis.

Main Results:

A total of 24 studies with 4473 participants were included in this updated review.
Cranberry products showed no significant reduction in symptomatic UTIs compared to placebo or no treatment (RR 0.86, 95% CI 0.71 to 1.04).
No significant differences were observed between cranberry products and antibiotics, with high dropout rates attributed to poor palatability and lack of standardized product potency.

Conclusions:

Evidence suggests cranberry juice is less effective for UTI prevention than previously indicated.
Due to poor acceptability and lack of statistically significant benefits, cranberry juice is not recommended for UTI prevention.
Standardization of cranberry product potency is crucial for future clinical evaluations.