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Survival after alcohol septal ablation for obstructive hypertrophic cardiomyopathy

Paul Sorajja1, Steve R Ommen, David R Holmes

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. paul.sorajja@mayo.edu

Circulation
|October 19, 2012
PubMed

Insights

Long-term survival after alcohol septal ablation for obstructive hypertrophic cardiomyopathy (HCM) is favorable. Survival rates are comparable to the general population and surgical myectomy, with no increased sudden cardiac death risk.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Hypertrophic Cardiomyopathy Research

Background:

  • Alcohol septal ablation is a treatment for obstructive hypertrophic cardiomyopathy (HCM).
  • Long-term outcomes and survival following this procedure require further investigation.

Purpose of the Study:

  • To evaluate the long-term survival of patients who underwent alcohol septal ablation for obstructive HCM.
  • To compare survival rates with the general population and surgical myectomy.

Main Methods:

  • Retrospective analysis of 177 patients who underwent septal ablation at a tertiary HCM referral center.
  • Follow-up duration of 5.7 years.
  • Comparison of survival data with age- and sex-matched general population and surgical myectomy cohorts.

Main Results:

  • Survival free of all mortality was similar to the expected survival for the general population.
  • Survival rates were comparable to age- and sex-matched patients who underwent isolated surgical myectomy (8-year estimate: 79% vs. 79%).
  • Residual left ventricular outflow tract gradient post-ablation independently predicted better long-term survival.

Conclusions:

  • Alcohol septal ablation in carefully selected patients by experienced operators offers favorable long-term survival.
  • Survival outcomes are comparable to the general population and surgical myectomy.
  • The procedure does not appear to increase the risk of sudden cardiac death.
Abstract

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