Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Super-Cluster collimation for ultra-sensitive SPECT-PET: a simulation study.

Physics in medicine and biology·2025

Same author

Dual-photopeak joint image reconstruction for pinhole SPECT, PET and PET-SPECT.

Physics in medicine and biology·2025

Same author

Let's celebrate 25 years of [<sup>123</sup>I]I-FP-CIT SPECT.

European journal of nuclear medicine and molecular imaging·2025

Same author

Is the Time Right to Start Testing if Late-Onset Depression is Associated With the Development of an α-Synucleinopathy Like Parkinson's Disease? A Double Systematic Review and Meta-Analysis.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2025

Same author

Psychiatric comorbidity in substance use disorders, a systematic review of neuro-imaging findings.

Neuroscience and biobehavioral reviews·2025

Same author

Characterization of [<sup>11</sup>C]DASB and [<sup>18</sup>F]FE-PE2I using microPET imaging in SERT and DAT knockout rats.

Nuclear medicine and biology·2025

Search research articles

Related Experiment Video

Updated: May 17, 2026

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Published on: July 15, 2020

VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET.

Marlies C Goorden¹, Frans van der Have, Rob Kreuger

¹Delft University of Technology, Delft, The Netherlands.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|October 19, 2012

Summary

A new Versatile Emission Computed Tomography (VECTor) system enables simultaneous high-resolution imaging of both Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) tracers. This integrated device overcomes previous limitations, allowing for combined functional imaging in biological systems.

More Related Videos

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

Related Experiment Videos

Last Updated: May 17, 2026

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

Published on: July 15, 2020

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

Area of Science:

Medical Imaging
Nuclear Medicine
Biomedical Engineering

Background:

Current PET and SPECT imaging systems require separate setups for high-resolution imaging.
Simultaneous imaging of different radiotracers is limited, hindering comprehensive biological studies.

Purpose of the Study:

To introduce a novel Versatile Emission Computed Tomography (VECTor) system for simultaneous high-resolution imaging of PET and SPECT tracers.
To enable integrated, multi-modal functional imaging of biological systems.

Main Methods:

A novel cylindric collimator with 162 pinholes was integrated into an existing SPECT system (U-SPECT-II).
The system utilizes statistical image reconstruction to correct for energy-dependent blurring.
Simultaneous acquisition of gamma photons from both positron-electron annihilation and single-photon emitters onto the same detectors.

Main Results:

Achieved submillimeter resolution for both PET (<0.8 mm) and SPECT (0.5 mm) tracers simultaneously.
SPECT image quality was minimally affected by the presence of PET tracers, even at higher concentrations.
Demonstrated simultaneous acquisition of registered 3D and 4D functional images from living mice.

Conclusions:

The VECTor system provides simultaneous, high-resolution complementary information from SPECT and PET tracers.
This integrated imaging capability opens new avenues for studying biological systems in rodents.
Enables novel perspectives in preclinical research through combined functional imaging.