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Prevalence of group A genotype human rotavirus among children with dirarrhea in Thailand, 2009-2011

Ornwalan Maiklang1, Viboonsak Vutithanachot, Chanpim Vutithanachot

  • 1Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|October 20, 2012
PubMed

Insights

Group A rotavirus, a common cause of severe diarrhea in children, was investigated in Thailand. The prevalent G3P[8] genotype was identified, informing future vaccine development for rotavirus gastroenteritis.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Rotavirus is a leading cause of severe infantile diarrhea globally, particularly in developing nations.
  • Understanding rotavirus epidemiology is crucial for effective public health interventions and vaccine strategies.

Purpose of the Study:

  • To determine the prevalence and seasonal distribution of group A rotavirus infections in Thai children.
  • To identify circulating rotavirus genotypes for vaccine development.

Main Methods:

  • Retrospective analysis of stool samples from children with acute gastroenteritis or diarrhea.
  • Detection of group A rotaviruses using reverse transcription-polymerase chain reaction (RT-PCR).
  • Genotyping based on VP7 and VP4 genes, with phylogenetic analysis and GenBank comparison.

Main Results:

  • Group A rotaviruses were detected in 44.5% of 562 specimens.
  • The most common genotype identified was G3P[8] (60.4%), followed by G1P[8] (39.2%).
  • A low prevalence of G2P[4] (0.4%) was also observed.

Conclusions:

  • Group A rotavirus is a significant pathogen in Thai children presenting with gastroenteritis.
  • The predominance of the G3P[8] genotype in this cohort provides essential data for rotavirus vaccine strain selection in the region.

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