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Pseudomonas aeruginosa, an emerging pathogen among burn patients in Kurdistan Province, Iran

Enayat Kalantar1, Shadi Taherzadeh, Tayeb Ghadimi

  • 1Department of Microbiology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. kalantar_enayat@yahoo.com

The Southeast Asian Journal of Tropical Medicine and Public Health
|October 20, 2012
PubMed

Insights

Pseudomonas aeruginosa infections are common in Iranian burn patients. High rates of antibiotic resistance, including extended-spectrum beta-lactamase (ESBL) producers, were observed, necessitating infection control measures.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Burn Care

Background:

  • Burn injuries create a high risk for secondary infections.
  • Pseudomonas aeruginosa is a significant opportunistic pathogen in burn wound infections.
  • Antibiotic resistance in P. aeruginosa complicates treatment and increases morbidity.

Purpose of the Study:

  • To determine the incidence of P. aeruginosa infections in burn patients at Tohid Hospital, Iran.
  • To investigate antimicrobial resistance patterns, focusing on extended-spectrum beta-lactamase (ESBL) production.
  • To identify the prevalence of specific resistance genes (PER-1 and OXA-10) in P. aeruginosa isolates.

Main Methods:

  • Collection of 176 clinical specimens from 145 burn patients.
  • Detection of P. aeruginosa using standard microbiological techniques.
  • Antimicrobial susceptibility testing and double disc synergy test (DDST) for ESBL detection.
  • Polymerase chain reaction (PCR) for PER-1 and OXA-10 gene identification.

Main Results:

  • P. aeruginosa was detected in 100 isolates (incidence to be calculated based on total patients/specimens).
  • Common resistance observed against cefotaxime, ceftriaxone, and ciprofloxacin.
  • 28% of isolates were ESBL producers.
  • 48% and 52% of isolates carried PER-1 and OXA-10 genes, respectively.

Conclusions:

  • High prevalence of P. aeruginosa and significant rates of ESBL production, including PER-1 and OXA-10, in burn patients.
  • The findings highlight a concerning trend of antibiotic resistance in this patient population.
  • Urgent implementation of infection control strategies is recommended to prevent the spread of resistant strains.

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