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[Uric acid, cardiovascular events and renal dysfunction: a circumstantial connection?]
A Petriş1, Diana Cimpoeşu, O Petriş
1Universitatea de Medicină şi Farmacie "Grigore T. Popa" laşi, Facultatea de Medicină.
Insights
This study investigated hyperuricemia in cardiac patients, finding it linked to factors like sex, smoking, blood pressure, and ejection fraction. However, uric acid was not an independent risk factor for cardiovascular events in this diverse heart disease group.
Area of Science:
- Cardiology
- Nephrology
- Biochemistry
Background:
- Asymptomatic hyperuricemia's role in cardiovascular events and renal dysfunction is debated.
- Previous studies have explored the link between high uric acid levels and adverse health outcomes.
Purpose of the Study:
- To investigate the relationship between asymptomatic hyperuricemia, cardiovascular events, and renal dysfunction in patients admitted to an Intensive Cardiac Care Unit.
- To determine if serum uric acid is an independent risk factor in patients with various heart diseases.
Main Methods:
- Analysis of 163 patients admitted to an Intensive Cardiac Care Unit.
- Serum uric acid levels were measured, with a cut-off of 7 mg% defining hyperuricemia.
- Collected anthropometric, clinical, and paraclinical data, including creatinine clearance.
Main Results:
- Hyperuricemia (55 patients) was associated with differences in sex, smoking, diastolic blood pressure, and ejection fraction compared to normouricemia (108 patients).
- Patients with lower creatinine clearance (<60 ml/min) showed significantly higher serum uric acid, older age, renal dysfunction, and dyslipidemia.
- Dilated cardiomyopathy was more prevalent in the hyperuricemia group.
Conclusions:
- The study did not demonstrate uric acid as an independent risk factor in a mixed group of cardiac patients.
- Further research may be needed to clarify the specific role of uric acid in different cardiovascular conditions.
Aim:
The relationship between asymptomatic hyperuricemia, cardiovascular events and renal dysfunction was studied (affirmed or challenged) long time ago. To investigate this relationship we conducted this study.
Material And Methods:
We analyzed 163 patients consecutively admitted in the Intensive Cardiac Care Unit of the 1st Cardiology Clinic, County Hospital "St. Spiridon" Iasi. The cut-off value of serum uric acid was defined as 7 mg%. There were recorded anthropometric, anamnesis, clinical and paraclinical data.
Results:
We compared the normal uricemia group (108 patients) with the hyperuricemia group (55 patients). The serum uric acid value was 5.22 +/- 1.16 mg% in the normouricemia group and 8.58 +/- 1.86 mg% in the hyperuricemia group. The statistically significant differences between the two groups relate to sex, smoking as cardiovascular risk factor, diastolic blood pressure and ejection fraction (lower in the hyperuricemia group were the dilated cardiomyopathy prevail). If the patients are grouped according to creatinine clearance less than or greater than 60 ml/min we found statistically significant differences between the two groups in terms of serum uric acid value (p < 0.001), age (p < 0.001), renal dysfunction and dyslipidaemia (p 0.001).
Conclusions:
The analysis performed doesn't demonstrate the role of uric acid as independent risk factor in a group that includes patients with different heart diseases (dilated cardiomyopathy, ischemic heart disease or hypertension).
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