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Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
Published on: October 24, 2019
Noninvasive hemodynamic study of the pulmonary circulation
Flavia Corciovă1, A D Ciochină, D Zaharia
1University of Medicine and Pharmacy "Grigore. T. Popa", Iaşi.
Insights
Echocardiography accurately correlates with cardiac catheterization for pulmonary hypertension hemodynamic assessment. This noninvasive method is a reliable alternative for studying pulmonary circulation.
Area of Science:
- Cardiology
- Medical Imaging
- Pulmonary Hypertension
Background:
- Cardiac catheterization is the gold standard for pulmonary circulation hemodynamics but is invasive and costly.
- Echocardiography offers a reliable, noninvasive alternative for hemodynamic assessment.
Purpose of the Study:
- To evaluate the correlation between echocardiographic and cardiac catheterization-derived hemodynamic data in pulmonary hypertension patients.
- To establish echocardiography's utility as a noninvasive tool for pulmonary hypertension diagnosis and management.
Main Methods:
- A prospective study involving 55 pulmonary hypertension patients.
- Simultaneous echocardiography and cardiac catheterization measurements of pulmonary artery pressures and resistance.
- Pearson correlation coefficient analysis to compare data from both methods.
Main Results:
- Strong correlations were observed between echocardiography and cardiac catheterization for systolic pulmonary artery pressure (r=0.847), mean pulmonary artery pressure (r=0.7), and pulmonary vascular resistance (r=0.82).
- A moderate correlation was found for diastolic pulmonary artery pressure (r=0.54).
- All correlations were statistically significant (p < 0.01).
Conclusions:
- Echocardiography demonstrates excellent agreement with cardiac catheterization for hemodynamic evaluation in pulmonary hypertension.
- Echocardiography is a highly effective, noninvasive method for assessing pulmonary circulation hemodynamics.
Unlabelled:
Cardiac catheterization is the reference method for the hemodynamic study of the pulmonary circulation. However, cardiac catheterization is an expensive and invasive method. Echocardiography is a reliable noninvasive alternative method. The purpose of our study was to determine the correlation between echocardiographic and haemodynamic data obtained by cardiac catheterization in patients with pulmonary hypertension.
Material And Methods:
We conducted a prospective study on 55 subjects diagnosed with pulmonary hypertension. They were examined by echocardiography and cardiac catheterization. The following parameters were measured: systolic, mean and diastolic pulmonary artery pressure and pulmonary vascular resistance. We determined the coefficient of linear correlation (Pearson) between the two methods.
Results:
The mean pulmonary artery pressure obtained by cardiac catheterization was 48.82 +/- 18.4 mm Hg; the systolic pulmonary artery pressure at cardiac catheterization was 67.86 +/- 22.31 mm Hg; the diastolic pulmonary artery pressure was 32.85 +/- 15.49 mm Hg; the pulmonary resistance was 10.4 +/- 5.14 Wood units. We obtained very good correlation between the two methods for systolic pulmonary artery pressure (r 0.847, p < 0.0001), mean pulmonary artery pressure (r 0.7, p < 0.001), diastolic pulmonary artery pressure (r 0.54, p 0.01) and pulmonary vascular resistance (r 0.82, p < 0.001).
Conclusions:
Echocardiography is an excellent method for the hemodynamic study of the pulmonary circulation.

