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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
[The characteristics of orofacial clefts in small communities]
Georgeta Zegan1, Gabriela Lesner
1Disciplina de Ortodonţie şi Ortopedie Dento-facială, Facultatea de Medicină Dentară, Universitatea de Medicini şi Farmacie "Grigore T. Popa"--Iaşi
Insights
The incidence of orofacial clefts in institutionalized children decreased significantly between 1987 and 1997. Cleft lip and palate was the most common type, with correlations found with various factors.
Area of Science:
- Pediatric Medicine
- Public Health
- Genetics
Context:
- Orofacial clefts represent a significant congenital anomaly with potential long-term health and social implications.
- Institutionalized children may face unique challenges and environmental factors influencing health outcomes.
- Understanding prevalence and associated factors is crucial for targeted interventions and resource allocation.
Purpose:
- To determine the prevalence of orofacial clefts in institutionalized children in Iasi.
- To investigate correlations between orofacial clefts and factors such as sex, birth weight, environment, maternal age, and associated diseases.
- To analyze trends in orofacial cleft incidence over a decade.
Summary:
- A study of 37 institutionalized newborns with orofacial clefts (1987-1997) in Iasi revealed a decreasing incidence from 7.42% to 2.18%.
- Cleft lip and palate was most frequent (54.06%), followed by cleft lip (37.84%) and cleft palate (8.10%).
- Significant correlations were identified between cleft types and sex, birth weight, environment, maternal age, and associated diseases.
Impact:
- The findings highlight a declining trend in orofacial clefts among institutionalized children, suggesting potential improvements in prenatal care or environmental factors.
- The study underscores the high prevalence of combined cleft lip and palate and associated complications, emphasizing the need for comprehensive management.
- Results indicate the importance of considering multiple factors in the etiology and management of orofacial clefts, guiding future research and clinical practice.
Aim:
Establishing the prevalence of orofacial clefts in a community of institutionalized children and the correlations with sex, weight at birth, life environment, maternal age and children's associated diseases.
Material And Methods:
The study was conducted on a batch of 37 living newly-born (15 boys and 22 girls) from 1987 to 1997, with orofacial clefts, institutionalized in placement centers from Iasi, who survived and were treated medical and surgical. The data were collected from the records found in the archives of these centers and were statistically processed with the EpiInfo 3.4.3. software a Center for Disease Control and Prevention C.D.C. (U.S.A.).
Results:
In 1987, children with orofacial clefts represented 7.42% and in 1997, 2.18% from the total of all children institutionalized. The average rate of prevalence of live births with orofacial clefts was 3.7/year. The frequency of clefts lip and palate in children who survived was 54.06%, clefts lip was 37.84% and clefts palate of 8.10%. Statistically significant correlations were found between the types of orofacial clefts and sex, weight at birth, life environment, maternal age and children's associated diseases (Fcalculat > F(Fisher)).
Conclusions:
The results confirm the decreased incidence of children with orofacial clefts, the high prevalence of clefts lip and palate the existence of orofacial cleft complications and the need for orthodontic treatment.
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