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Updated: May 17, 2026
07:11
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
High- versus low-density multifocal pupillographic objective perimetry in glaucoma.
Ted Maddess1, Rohan W Essex, Maria Kolic
1The ARC Vision Centre, John Curtin School of Medical Research, Australian National University, Australia. ted.maddess@anu.edu.au
Clinical & Experimental Ophthalmology
|October 20, 2012
Summary
Increasing multifocal pupillographic objective perimetry (MPOP) regions from 24 to 44 significantly improved glaucoma detection accuracy. MPOP offers valuable data on response delay and visual pathway defects, serving as a potential perimetry adjunct.
Area of Science:
- Ophthalmology
- Visual Neuroscience
Background:
- Multifocal pupillographic objective perimetry (MPOP) is an emerging diagnostic tool.
- Previous studies have not fully explored the impact of visual field density on MPOP's diagnostic capabilities.
Purpose of the Study:
- To compare the diagnostic accuracy of MPOP using 24 versus 44 regions within the central visual field.
- To evaluate the influence of stimulus presentation rate on MPOP performance.
Main Methods:
- A university-based experimental design involving 27 normal controls and 36 glaucoma patients.
- Four MPOP test variants were employed, differing in stimulus interval (4, 1, or 0.25 s) and tested regions (24 or 44).
- Glaucoma diagnosis was confirmed using optical coherence tomography, standard perimetry, and slit-lamp biomicroscopy.
Main Results:
- Increasing tested regions from 24 to 44 significantly improved diagnostic accuracy, with the 44-region protocol achieving an area under the curve of 93.2 ± 3.89%.
- Presentation rate had minimal impact on sensitivity.
- Age and female gender showed small but significant effects on sensitivity.
Conclusions:
- A higher density of tested regions (44) in MPOP enhances diagnostic power for glaucoma detection.
- MPOP provides additional valuable information regarding response delays and afferent/efferent pathway defects.
- MPOP may serve as a valuable complementary tool to existing perimetry methods for glaucoma assessment.
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