Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucagon increases hepatic efficacy for urea synthesis.

H Vilstrup1, B A Hansen, T P Almdal

  • 1Division of Hepatology, Rigshospitalet, Copenhagen, Denmark.

Journal of Hepatology
|January 1, 1990
PubMed
Summary

Glucagon enhances urea synthesis and nitrogen clearance in healthy volunteers. This hormone increases the liver

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Data on the use of dietary supplements in Danish patients with type 1 and type 2 diabetes.

Data in brief·2018
Same author

The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Helicobacter pylori infection is not associated with rheumatoid arthritis.

Scandinavian journal of rheumatology·2018
Same author

The continuous reaction time test for minimal hepatic encephalopathy validated by a randomized controlled multi-modal intervention-A pilot study.

PloS one·2017
Same author

Letter: autoimmune hepatitis-drug-induced liver injury must always be excluded. Authors' reply.

Alimentary pharmacology & therapeutics·2017

Area of Science:

  • Metabolic physiology
  • Hormonal regulation
  • Nitrogen metabolism

Background:

  • Urea synthesis is a key process for nitrogen excretion.
  • Amino acid levels influence urea production.
  • The role of glucagon in this relationship requires further elucidation.

Purpose of the Study:

  • To investigate the effect of glucagon on urea synthesis.
  • To examine the relationship between blood amino acid concentrations and urea production.
  • To assess glucagon's impact on hepatic nitrogen clearance.

Main Methods:

  • Infusion of alanine in seven healthy volunteers.
  • Measurement of urea nitrogen synthesis rate.
  • Administration of glucagon during a portion of the study.

Main Results:

  • Urea synthesis was linearly related to alanine concentration.
  • Glucagon significantly increased urea synthesis rate.
  • Glucagon enhanced hepatic nitrogen clearance and reduced blood alanine levels.

Conclusions:

  • Glucagon increases the efficiency of urea synthesis.
  • This hormonal effect is important for nitrogen homeostasis.
  • Glucagon plays a role in regulating amino acid metabolism and nitrogen balance.

Related Experiment Videos