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Diclofenac associated hepatitis.

T J Iveson1, N G Ryley, P M Kelly

  • 1Department of Gastroenterology, John Radcliffe Hospital, Headington, Oxford, U.K.

Journal of Hepatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Diclofenac, a common non-steroidal anti-inflammatory drug, was linked to five cases of acute hepatitis. Liver dysfunction resolved in most patients after discontinuing diclofenac, suggesting it may be a more frequent cause of hepatitis than previously thought.

Area of Science:

  • Hepatology
  • Pharmacology
  • Gastroenterology

Background:

  • Diclofenac is a globally prevalent non-steroidal anti-inflammatory drug (NSAID).
  • NSAIDs are frequently prescribed for pain and inflammation management.
  • Previous reports of diclofenac-induced hepatotoxicity are limited.

Observation:

  • This study details five cases of acute hepatitis with clear links to diclofenac use.
  • Patients presented with jaundice and significantly abnormal liver function tests.
  • Four out of five patients initiated diclofenac within three months prior to presentation.

Findings:

  • Liver biopsies in four patients revealed acute hepatitis with inflammation and hepatocyte damage.
  • Hepatotoxicity was directly attributed to diclofenac in these cases.

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  • Four patients recovered fully within three months of drug withdrawal; one developed chronic active hepatitis.

    • Implications:

    • Diclofenac-induced hepatitis may be more common than previously recognized.
    • Clinicians should consider diclofenac as a potential cause of acute liver injury.
    • Further research is warranted to understand the incidence and mechanisms of diclofenac hepatotoxicity.