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Updated: May 17, 2026
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Electrophysiological features in dogs with peripheral nerve sheath tumors: 51 cases (1993-2010)
Matthias le Chevoir1, Jean Laurent Thibaud, Julien Labruyère
1Unité de neurologie, Ecole Nationale Vétérinaire d'Alfort, Université Paris Est, 94700 Maisons Alfort, France. mlechevoir@yahoo.fr
Objective:
To determine the electrophysiological changes in dogs with peripheral nerve sheath tumors (PNSTs), evaluate the prevalence of these changes, assess the correlation between spontaneous activity in epaxial muscles and proximal invasion by the tumor, and evaluate whether knowledge of electrophysiological changes could be helpful in the imaging diagnosis via CT or MRI.
Design:
Retrospective case series.
Animals:
51 dogs with a histologic (n = 18) or a suspected (33) diagnosis of PNST.
Procedures:
Clinical, postmortem, and histologic reports and details of electrodiagnostic procedures and CT or MRI reports were studied. Twenty-four CT and 6 MRI reports for dogs with PNSTs were reviewed by a single observer blinded to the diagnosis.
Results:
Only 2 of the 51 dogs had no electrophysiological changes. The most commonly affected muscles were those innervated by the radial, ulnar, median, tibial-sciatic, and peroneal nerves. Abnormal spontaneous epaxial muscle activity was significantly more frequent in the group with foraminal or spinal invasion by the tumors. Knowledge of the electrophysiological changes increased diagnostic accuracy of CT.
Conclusions And Clinical Relevance:
Results suggested that electrophysiological studies may be sensitive for the detection of PNST and helpful in the imaging diagnosis. Epaxial electromyographic abnormalities appeared to be predictive for intervertebral or vertebral canal invasion by PNSTs in dogs.
