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Updated: May 17, 2026

Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection

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Published on: November 22, 2013

Humidifier-associated paediatric Legionnaires' disease, Israel, February 2012.

J Moran-Gilad¹, T Lazarovitch, M Mentasti

¹Division of Epidemiology, Public Health Services, Ministry of Health, Jerusalem, Israel. giladko@014.net.il

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin

|October 20, 2012

Summary

This summary is machine-generated.

A fatal case of Legionnaires' disease in an infant was linked to a contaminated humidifier. This highlights the risk of humidifier-associated Legionnaires' disease and the utility of sequence-based typing (SBT) in investigations.

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Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

Published on: February 22, 2017

Area of Science:

Infectious Diseases
Public Health
Microbiology

Background:

Legionnaires' disease is a severe pneumonia caused by Legionella bacteria.
Community-acquired Legionnaires' disease (CALD) typically affects older adults, with cases in infants being rare.
Contaminated water sources, particularly aerosol-generating devices, are common sources of Legionella transmission.

Observation:

A fatal case of community-acquired Legionnaires' disease occurred in an infant under six months old.
The infection was traced to a free-standing cold water humidifier.
The humidifier used domestic tap water contaminated with Legionella pneumophila serogroup 1.

Findings:

Epidemiological and microbiological data strongly implicated the humidifier as the source of infection.
Sequence-based typing (SBT) confirmed the link between the clinical isolate and the environmental source.
This case demonstrates humidifier-associated Legionnaires' disease transmission.

Implications:

Appropriate control measures for domestic humidifiers are crucial for preventing Legionnaires' disease.
Sequence-based typing (SBT) is an emerging and valuable tool for investigating legionellosis outbreaks.
This case underscores the importance of considering environmental sources in pediatric infectious disease investigations.