Related Experiment Video
Updated: May 17, 2026

Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
Published on: November 22, 2013
Humidifier-associated paediatric Legionnaires' disease, Israel, February 2012
J Moran-Gilad1, T Lazarovitch, M Mentasti
1Division of Epidemiology, Public Health Services, Ministry of Health, Jerusalem, Israel. giladko@014.net.il
Insights
A fatal case of Legionnaires' disease in an infant was linked to a contaminated humidifier. This highlights the risk of humidifier-associated Legionnaires' disease and the utility of sequence-based typing (SBT) in investigations.
Area of Science:
- Infectious Diseases
- Public Health
- Microbiology
Background:
- Legionnaires' disease is a severe pneumonia caused by Legionella bacteria.
- Community-acquired Legionnaires' disease (CALD) typically affects older adults, with cases in infants being rare.
- Contaminated water sources, particularly aerosol-generating devices, are common sources of Legionella transmission.
Observation:
- A fatal case of community-acquired Legionnaires' disease occurred in an infant under six months old.
- The infection was traced to a free-standing cold water humidifier.
- The humidifier used domestic tap water contaminated with Legionella pneumophila serogroup 1.
Findings:
- Epidemiological and microbiological data strongly implicated the humidifier as the source of infection.
- Sequence-based typing (SBT) confirmed the link between the clinical isolate and the environmental source.
- This case demonstrates humidifier-associated Legionnaires' disease transmission.
Implications:
- Appropriate control measures for domestic humidifiers are crucial for preventing Legionnaires' disease.
- Sequence-based typing (SBT) is an emerging and valuable tool for investigating legionellosis outbreaks.
- This case underscores the importance of considering environmental sources in pediatric infectious disease investigations.
Abstract:
We report a fatal case of community-acquired Legionnaires' disease in an infant aged under six months. Epidemiological and microbiological investigations suggested that a free-standing cold water humidifier using domestic tap water contaminated with Legionella pneumophila serogroup 1 served as a vehicle for infection. These findings were corroborated by sequence-based typing (SBT). Humidifier-associated Legionnaires' disease can be prevented by appropriate control measures. This case also illustrates the emerging role of SBT in the investigation of legionellosis.
Related Concept Videos
Atypical Pneumonia
Pneumonia II: Pathophysiology
Pneumonia I: Introduction
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Diphtheria
Pneumonia III: Complications and Assessment
