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Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses

Kevin Messacar1, Christine C Robinson, Dayanand Bagdure

  • 1Children's Hospital Colorado, Section of Infectious Diseases, Aurora, CO 80045, United States. kevin.messacar@childrenscolorado.org

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|October 20, 2012
PubMed

Insights

Human rhino/enteroviruses (HRV/EV) and influenza viruses cause similar severe respiratory illness in hospitalized children. HRV/EVs are common, leading to significant disease, but with no reported deaths in this study.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory medicine

Background:

  • The comparative impact of human rhino/enteroviruses (HRV/EV) versus influenza viruses on hospitalized children remains unclear.
  • Understanding these differences is crucial for managing pediatric respiratory infections.

Purpose of the Study:

  • To compare the epidemiology and clinical features of children hospitalized with HRV/EV infections against those hospitalized with influenza virus.
  • To assess the relative severity and outcomes of these viral infections in pediatric patients.

Main Methods:

  • A retrospective chart review was conducted on hospitalized children from January 2009 to December 2009.
  • Respiratory specimens were tested using multiplex PCR for 16 respiratory viruses, focusing on HRV/EV and influenza virus single infections.

Main Results:

  • HRV/EVs were detected more frequently (18.6%) than influenza virus (8.8%) in hospitalized children.
  • Children with HRV/EV showed increased respiratory distress symptoms (e.g., work of breathing, crackles, wheezing) compared to influenza patients.
  • Despite similar ICU admission rates, HRV/EV patients had shorter hospital stays, fever duration, and hypoxemia duration, with no reported deaths, unlike influenza cases.

Conclusions:

  • Human rhino/enteroviruses are prevalent pathogens in hospitalized children, causing severe lower respiratory tract disease.
  • The morbidity associated with HRV/EV infections is comparable to that of influenza viruses in this pediatric population.
  • HRV/EVs represent a significant cause of serious respiratory illness in children, necessitating further clinical and public health attention.
Abstract

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