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Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
Koneni V Sashidhara1, Gopala Reddy Palnati, Ranga Prasad Dodda
1Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India. kv_sashidhara@cdri.res.in
Abstract:
A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.
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