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Related Experiment Video

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Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
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Predisposing factors for solution-induced corneal staining.

Graeme Young1, Kristy Canavan, Susanna Jones

  • 1Visioncare Research Ltd., Farnham, UK. g.young@visioncare.co.uk

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|October 20, 2012
PubMed
Summary
This summary is machine-generated.

Poor tear quality is a key factor in solution-induced corneal staining (SICS) for soft contact lens wearers. This study identified specific ocular surface signs associated with SICS susceptibility.

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Area of Science:

  • Ophthalmology
  • Corneal Physiology
  • Contact Lens Technology

Background:

  • Solution-induced corneal staining (SICS) is a common complication for soft contact lens wearers.
  • Identifying predisposing factors is crucial for preventing SICS and improving patient outcomes.

Purpose of the Study:

  • To evaluate predisposing factors in subjects susceptible to solution-induced corneal staining (SICS).
  • To identify clinical signs associated with SICS in soft contact lens wearers.

Main Methods:

  • 446 soft contact lens wearers were fitted with lotrafilcon B or omafilcon A lenses.
  • Subjects used a hydrogen peroxide care system, followed by a multipurpose solution challenge.
  • Subjects were categorized as 'stainers' or 'non-stainers' based on corneal staining patterns.

Main Results:

  • 36% of subjects were classified as stainers, with a higher proportion using omafilcon A lenses.
  • Stainers exhibited poorer lens wetting and increased ocular surface signs like hyperemia and tarsal roughness.
  • Stainers showed significantly higher rates of corneal and conjunctival staining compared to non-stainers.

Conclusions:

  • Poor tear quality appears to be a significant predisposing factor for SICS.
  • Specific ocular surface characteristics are associated with increased susceptibility to SICS.