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Updated: May 17, 2026
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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide
1Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270 Paris, France.
Abstract
Introduction:
The mast cell is an immunocyte, but its functions in the brain remain unclear.
Materials And Methods:
In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.
Conclusion:
We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
