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The IMGT/HLA database.

James Robinson1, Jason A Halliwell, Hamish McWilliam

  • 1HLA Informatics Group, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.

Nucleic Acids Research
|October 20, 2012
PubMed
Summary
This summary is machine-generated.

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The IMGT/HLA database provides curated human leukocyte antigen (HLA) sequences for researchers. Recent updates enhance this vital resource for immunology and clinical applications.

Area of Science:

  • Immunogenetics
  • Bioinformatics
  • Molecular Biology

Background:

  • The IMGT/HLA database has served the human leukocyte antigen (HLA) community for 14 years.
  • The HLA complex on chromosome 6p21.3 contains over 220 genes, including 21 highly polymorphic immune system genes.
  • The World Health Organization Nomenclature Committee oversees HLA gene and allele naming and quality control.

Purpose of the Study:

  • To report the latest updates and new tools for the IMGT/HLA database.
  • To ensure continued public access to curated HLA sequence data.
  • To support the HLA research and clinical communities with updated information.

Main Methods:

  • Maintaining a searchable repository of highly curated HLA sequences.
  • Collaborating with the European Bioinformatics Institute for public data access via a dedicated website.

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  • Implementing regular updates to incorporate new and confirmatory sequences.

    • Main Results:

    • The IMGT/HLA database continues to provide essential, curated HLA sequence data.
    • The project website (http://www.ebi.ac.uk/imgt/hla/) offers public access to these data.
    • Recent updates and additional tools have been added to the IMGT/HLA project.

    Conclusions:

    • The IMGT/HLA database remains a critical resource for the HLA research and clinical fields.
    • Regular updates ensure the database reflects the latest discoveries in HLA genetics.
    • Enhanced tools and data accessibility support advancements in immunology and transplantation.